Publications

Control of synaptic connectivity by an interacting network of Drosophila IgSF cell surface proteins. Carrillo RA*, Özkan E*§, Menon K*, Nagarkar-Jaiswal S, Lee PT, Jeon M, Birnbaum ME, Bellen HJ, Garcia KC, Zinn K§. Cell 163, 1770 (2015). (* equal contribution, § corresponding authors) PDF

"Velcro" Engineering of High Affinity CD47 Ectodomain as Signal Regulatory Protein α (SIRPα) Antagonists That Enhance Antibody-dependent Cellular Phagocytosis. Ho CC, Guo N, Sockolosky JT, Ring AM, Weiskopf K, Özkan E, Mori Y, Weissman LI, Garcia KC. J Biol Chem 290, 12650 (2015).

Structure of an intermediate conformer of the Spindle Checkpoint protein Mad2. Hara M*, Özkan E*, Sun H, Yu H, Luo X. Proc Natl Acad Sci U S A. 112, 11252 (2015). (* equal contribution)

Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis. Özkan E, Chia PH, Wang RR, Goriatcheva N, Borek D, Otwinowski Z, Walz T, Shen K, Garcia KC. Cell 156, 482 (2014). (See the cover on the right sidebar.) PDF

Deconstructing the peptide-MHC specificity of T cell recognition. Birnbaum ME, Mendoza JL, Sethi DK, Dong S, Glanville J, Dobbins J, Özkan E, Davis MM, Wucherpfennig KW, Garcia KC. Cell 157, 1073 (2014).

An extracellular interactome of immunoglobulin and LRR proteins reveals receptor-ligand networks. Özkan E, Carrillo RA, Eastman CL, Weiszmann R, Waghray D, Johnson KG, Zinn K, Celniker SE, Garcia KC. Cell 154, 228 (2013). PDF

Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies. Weiskopf, K, Ring AM, Ho CCM, Levin AM, Volkmer J-P, Volkmer AK, Özkan E, van de Rijn M, Weissman IL, Garcia KC. Science 341, 228.

Plum, an Immunoglobulin Superfamily Protein, Regulates Axon Pruning by Facilitating TGF-β Signaling. Yu XM, Gutman I, Mosca TJ, Iram T, Özkan E, Garcia KC, Luo L, Schuldiner O. Neuron 78, 456 (2013).

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Ring AM, Lin JX, Feng D, Mitra S, Rickert M, Bowman GR, Pande V, Li P, Moraga I, Spolski R, Özkan E, Leonard WJ, Garcia KC. Nat Immunol 13, 1187 (2012).

Molecular and structural insight into proNGF engagement of p75NTR and sortilin. Feng D, Kim T, Özkan E, Light M, Torkin R, Teng KK, Hempstead BL, Garcia KC. J Mol Biol 396, 967 (2010).

Gabapentin receptor α2δ-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Eroglu C, Allen NJ, Susman MW, O'Rourke NA, Park CY, Özkan E, Chakraborty C, Mulinyawe SB, Annis DS, Huberman AD, Green EM, Lawler J, Dolmetsch R, Garcia KC, Smith SJ, Luo ZD, Rosenthal A, Mosher DF, Barres BA. Cell 139, 380 (2009).

Structures of neuroligin-1 and the neuroligin-1/neurexin-1β complex reveal specific protein-protein and protein-Ca2+ interactions. Araç D, Boucard AA, Özkan E, Strop P, Newell E, Südhof TC, Brunger AT. Neuron 56, 992 (2007).

Mechanistic Insight into the Allosteric Activation of a Ubiquitin-Conjugating Enzyme by RING-type Ubiquitin Ligases. Özkan E, Yu, H., Deisenhofer, J. Proc Natl Acad Sci U S A 102, 18890 (2005).

APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. Tang Z, Li B, Bharadwaj R, Zhu H, Özkan E, Hakala K, Deisenhofer J, Yu H. Mol Biol Cell 12, 3839 (2001).

The plug domain of FepA, a TonB-dependent transport protein from Escherichia coli, binds its siderophore in the absence of the transmembrane barrel domain. Usher KC, Özkan E, Gardner KH, Deisenhofer J. Proc Natl Acad Sci U S A 98, 10676 (2001).


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